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Dozamet 400mg Tablets
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(Cimetidine)
400mg (1x10's)

The Logical Choice for the Treatment of
  • Dyspepsia
  • Benign Gastric Ulcer
  • Heart Burn
  • Acute Duodenal Ulcer
  • Belching
  • Recurrent Ulceration
  • Abdominal Distention
  • Prevention of Peptic
       Ulcer Relapses
  • Post Prandial Distress
  • Reflux Oesophagitis
  • Unbalanced Diet
  • Zollinger Ellison
       Syndrome
  • "Antihistamines can alleviate symptoms of acute widespread urticaria H2-antagonists such as cimetidine can be a useful adjunct, as can mast cell stabilizers".

    "Ref: DAVIDSON'S PRINCIPLES AND PRACTICE OF MEDICINE, 18TH Ed. 1999, Page No. 889".


    Dosage And Administration

    Non-ulcer dyspepsia, Heart burn, Abdominal Distention, Belching, Post prandial Distress & Unbalanced Diet 400mg twice daily.

    Acute duodenal ulcer 800mg at bedtime for at least 4 weeks.

    Benign gastric ulcer 800mg at bedtime for at least 6 weeks.

    Recurrent ulceration 400mg twice daily for 4-6 weeks.

    Prevention of peptic ulcer relapses 400mg at bedtime continuous treatment.


    Prescribing Information

    Dozamet Cimetidine is a histamine H2 Receptor antagonist which inhibits both basal and stimulated gastric acid secretion and reduces pepsin output. Indications: Dozamet is indicated in the treatment of duodenal and benign gastric ulceration, recurrent and stomal ulceration, oesophageal reflux disease and other conditions where reduction of gastric acid by "Dozamet" has been shown to be beneficial. "Dozamet" is also useful in patients with persistent dyspeptic symptoms with or without ulceration, particularly meal related upper abdominal pain, the prophylaxis of gastrointestinal hemorrhage from stress ulceration in seriously ill patients. "Dozamet" is also recommended in the management of Zollinger-Ellison Syndrome.


    Presentation
    Dozamet 400 mg tablets in blister pack of 2x10's.

    Contra-Indications
    No known contra-indication.

    Precaution

    Dosage should be reduced in patients with impaired renal function according to creatinine clearance.


    Dosage and Administration

    ADULTS
    In duodenal ulcer the recommended dosage is 800mg at bedtime. Alternatively, patients with duodenal ulcer may be treated with 400mg twice a day at breakfast and at bedtime. In dyspepsia (gastritis/duodenitis) gastric ulcer, stomal and recurrent ulceration and the short bowel syndrome the usual dosage is 400mg at breakfast and at bedtime. Other effective regimens are 200mg three times a day with meals and 400mg at bedtime. Treatment should be given initially for at least four weeks (six weeks in benign gastric ulcer) even if symptomatic relief has been achieved sooner. Treatment may be continued for longer periods in those patients who may benefit from reduction of gastric secretion and the dosage may be reduced in those who have responded to the treatment. In patients with benign peptic ulcer disease who have responded to initial course, relapse may be prevented by continued treatment. The usual dosage for maintenance treatment is 400mg at bedtime, or in occasional cases further.


    Use in Pregnancy and Lactation

    As with most drugs, the use of Dozamet should be avoided during pregnancy and lactation unless essential.


    Adverse Reaction

    More then 30 million patients have treated with cimetidine worldwide and adverse reaction been infrequent. Diarrhoea, dizziness or rash, usually, mild and transient, tiredness have been reported. Gynecomastia has been reported and is almost reversible on discontinuing treatment. There have been very rare reports of interstitial nephritis, acute pancreatitis, thrombocytopenia, headach, myalgia and arthralgia, all reversible on withdrawal of treatmet. Alopacia has been reported but no casual relationship has been established. Reversible impotence has also been very rarely reported but no casual relationship has been established at usual therapeutic dose.

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