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Malagon Syrup
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(Sulfadoxine+Pyrimethamine)
15ml

Composition
Each teaspoon (5ml) contains:
Sulfadoxine 500 mg.
Pyrimethamine 25 mg.

Pharmacological Properties

The synergistic combination of Sulfadoxine and pyrimethamine. These ingredients act by blocking two enzymes involved in biosynthesis of folinic acid in parasites. Malagon (Sulfadoxine & Pyrimethamine) is also sensitive and most effective to resistant organisms, to conventional antimalarials like Chloroquine and its derivatives. The incidence of resistance with Malagon is rare and negligible.

Malagon is absorbed orally and excreted mainly by kidney. Following a single dose administration of Malagon (Sulfadoxine & Pyrimethamine). Sulfadoxine peak plasma concentration 51 to 76 mcg/ ml were achieved in 2.5 to 6 hours and Pyrimethamine peak plasma concentration 0.13 to 0.4 mcg/ml were achieved in 1.5 to 8 hours. The approximate elimination half life of Sulfadoxine ranges from 100 to 231 hours with a mean of 169 hours where as pyrimethamine half life ranges from 54 to 148 hours with a mean of 111 hours.

Indications

Malagon is indicated for the treatment and prophylaxis of malaria caused by plasmodium falciparum, plasmodium vivax, plasmodium ovale and plasmodium malariae. Malagon is also effective for chloroquine resistant malaria.

Malagon has also been found effective in infection caused by toxoplasma gondii.

Malagon is also effective for the prophylaxis of pneumonia due to pneumocystis carinii.


Contraindications

Malagon (Sulfadoxine + Pyrimethamine) is contraindicated in patients with known hypersensitivity to Sulfadoxine or Pyrimethamine. It should be avoided as safety is not established in pregnancy, lactation and premature babies.


Side Effects

Generally very well tolerated. Rarely reported in negligible cases of nausea, with or without vomiting, skin rashes. In rare cases headache, fatigue, fever is also reported.


Precautions

Malagon should be discontinued if skin rashes appear. Oral intake of fluid should be increased. To be given with caution in patients with hepatic damage.


Presentation
    15ml bottle.
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